In February 2015, the UK decided to create a controversial exception to its law against any form of human germline modification to allow the creation of “three-person embryos” to prevent the transmission of some mitochondrial disease. Then and now, unresolved scientific concerns remained, and many people have been waiting to see whether the science will indeed come through.
Adding to anxiety to see these data is the enormous global attention on a different technology proposed for human genetic modification: the gene editing technique CRISPR, and current controversy over varied attempts to try it on human embryos.
However, there is only one central place where the mitochondrial research is being carried out in the UK – the Wellcome Trust Centre for Mitochondrial Research at Newcastle University. But despite opening its doors in 2012 and encouraging excitement about the importance of this research, none of the specific research requested by the Human Fertilisation and Embryology Authority (HFEA) had been published until now.
Today, that changed. Well-known Newcastle researchers including Mary Herbert and Douglass Turnbull have just published an update to their six-years-old Nature paper, which originally described how their preferred form of mitochondrial replacement – pronuclear transfer (PNT) – “has the potential to prevent the transmission of mtDNA disease in humans.”
Shockingly, their new paper reports that the proof-of-concept studies upon which everyone had been basing their enthusiasm “were not well tolerated by normally fertilized zygotes.” In other words, the scientific basis for the controversial UK law and HFEA policy change turns out to have been unfounded. It did not work.
The views, opinions and positions expressed by these authors and blogs are theirs and do not necessarily represent that of the Bioethics Research Library and Kennedy Institute of Ethics or Georgetown University.