Bioethics Blogs

Human Germline Modification in the UK? Cries of Caution from all Corners

The UK House of Commons Science and Technology Committee held an evidence hearing on October 22 to discuss the science of what they euphemistically call “mitochondrial donation.”

The Committee has now published all of the evidence it received for that hearing. Out of twenty submissions, just five explicitly argue in favor of changing the current UK law prohibiting human inheritable genetic modification in order to allow three-person IVF. These arguments largely consist of emotional pleas from families that currently have a child suffering from mitochondrial disease, and that want to utilize the technology in an attempt to have an unaffected and genetically related child.

The other fifteen submissions warn that we are nowhere near being able to promise these families a healthy child. Three make the case that more evidence is needed prior to offering these techniques in fertility clinics. Twelve argue that the risks to women and children are so great that we need to rethink this entire route as a means to prevent inter-generational transmission of disease.

None of these detailed letters were mentioned at the hearing. When I wrote a blog about it a couple weeks ago, I used the provocative title, “What Good is a Scientific Meeting If You Dismiss the Science?” Now that I’ve seen all the evidence the Committee received, I’m wondering if “Dismiss” should be replaced with “Systematically Ignore.” In fact, one scientist who submitted an eleven-page correspondence on concerns about “the safety of the procedures and the health of the children created through them,” notes

The entire public debate and consultation process surrounding mitochondrial replacement has been based on disastrously flawed scientific assumptions.

The views, opinions and positions expressed by these authors and blogs are theirs and do not necessarily represent that of the Bioethics Research Library and Kennedy Institute of Ethics or Georgetown University.