Bioethics Blogs

Creative Minds: Studying the Human Genome in 3D

Jesse Dixon

As a kid, Jesse Dixon often listened to his parents at the dinner table discussing how to run experiments and their own research laboratories. His father Jack is an internationally renowned biochemist and the former vice president and chief scientific officer of the Howard Hughes Medical Institute. His mother Claudia Kent Dixon, now retired, did groundbreaking work in the study of lipid molecules that serve as the building blocks of cell membranes.

So, when Jesse Dixon set out to pursue a career, he followed in his parents’ footsteps and chose science. But Dixon, a researcher at the Salk Institute, La Jolla, CA, has charted a different research path by studying genomics, with a focus on understanding chromosomal structure. Dixon has now received a 2016 NIH Director’s Early Independence Award to study the three-dimensional organization of the genome, and how changes in its structure might contribute to diseases such as cancer or even to physical differences among people.

The human body is made up of trillions of cells, each much too small to see without a microscope. And yet, if you could unwind and stretch the DNA contained within the nucleus of any one of those vanishingly small cells, you’d find it’s more than 6 feet long!

How is that possible? It takes a lot of careful folding and packaging. It also requires that the genome is arranged to ensure that the right genes are activated in the right place and at the right time. That’s because DNA is not a disorganized mass of spaghetti in the nucleus.

The views, opinions and positions expressed by these authors and blogs are theirs and do not necessarily represent that of the Bioethics Research Library and Kennedy Institute of Ethics or Georgetown University.