Serotonin is implicated in functions as important as humour, sadness, feelings of aggression, anxiety and sleep disturbances, among others. A deficiency in serotonin release has been related with schizophrenia, depression, bipolar disorder, obsessive-compulsive disorders, chronic pain and eating disorders. All of this supports how important it is for the central nervous system to function well. Now, to facilitate “in-vitro” studies of the neurons that produce this substance, a technique has been developed that enables them to be obtained from human pluripotent cells, both embryonic and human iPS cells (Nature Biotechnology 34; 89-94, 2016). The use of human embryonic stem cells has objective ethical difficulties, but not so human iPS cells, so their use opens up a scientific and ethical avenue for the production this substance from neurons, and to take another step forward in the treatment of conditions linked to serotonin imbalance.
La entrada Serotonin produced from neurons obtained with iPS and embryonic stem cells aparece primero en Bioethics Observatory.
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