December 13, 2016
(The Scientist) – After human somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), the resulting cells retain both genetic and epigenetic indicators of the age of the person who donated the somatic-cell progenitors, scientists have found. Ali Torkamani, Kristin Baldwin, and their colleagues at the Scripps Research Institute in California have found that iPSC genomes have methylation patterns that reflect donor age. In general, the number of mutations those pluripotent cells carry increases with donor age—until around age 90, that is, when the number of mutations decreases, the researchers found.
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