November 1, 2016
(New Scientist) – The latest warning that medical research is barking up the wrong tree comes from Joseph Garner of Stanford University in California (see “Lab mice are sending us on a wild goose chase“). Garner is interested in why so few new drugs that get into clinical trials actually make it to market, and says that one important contributor is animal models that do not genuinely model human disease. For example, drug research on cognitive conditions relies heavily on animals that have been genetically manipulated into displaying characteristics that are Parkinson’s-like, OCD-like, anxiety-like, autism-like – you name it, there’s probably a mouse, or a primate, for it.
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