Bioethics Blogs

Genome editing – the key ethical issues

Written by Dr Christopher Gyngell

This article originally appeared on the OMS website

The Nuffield Council of Bioethics released a report last Friday outlining the key ethical issues raised by genome editing technologies.

Genome editing (GE) is a powerful, and extremely rapidly developing technology. It uses engineered enzymes to make precise, controlled modification to DNA. It has the potential to radically transform many industries, including medicine, agriculture and ecology.  Despite only being developed in the past few years’, GE has already been used to create malaria-fighting mosquitoes, drought resistant wheat, hornless cows and cancer killing immune cells. The potential applications of GE in a decade are difficult to imagine. It raises a wide range of ethical issues that require careful scrutiny.

The Nuffield Council of Bioethics has formed a working group to analyse these issues. Their report titled “Genome editing: an ethical review”, is the first output of this working group.  It is a mapping project which identifies the major ethical issues arising from GE.

The report identifies several areas of GE that raise pressing ethical issues.  GE for human reproduction, and GE in livestock, are classed as requiring ‘urgent’ attention. GE for the purposes of xenotransplantation, and to alter wild populations of mosquitoes (and other disease causing animals), are classed as requiring attention ‘in the near future’.

It is unsurprising that genome editing for human reproduction is listed as requiring urgent attention. It has been at the centre of public debates about GE since scientists used the technology to alter human embryos for the first time last year.

The views, opinions and positions expressed by these authors and blogs are theirs and do not necessarily represent that of the Bioethics Research Library and Kennedy Institute of Ethics or Georgetown University.