LabTV: Curious about Computer Modeling of Proteins

In many ways, Josh Carter is a typical college student, with a hectic schedule packed with classes and social activities. But when he enters a structural biology lab at Montana State University in Bozeman, Carter encounters an even faster paced world in which molecular interactions can be measured in femtoseconds—that is, 1 millionth of 1 billionth of 1 second.

Working under the expert eye of principal investigator Blake Wiedenheft, Carter is applying his computational skills to X-ray crystallography data to model the structures of various proteins, as well as to chart their evolution over time and map their highly dynamic interactions with other proteins and molecules. This basic science work is part of this NIH-funded lab’s larger mission to understand how bacteria defend themselves from the viruses that try to infect them. It’s a fascinating area of science with a wide range of potential applications, from treating diseases that arise from imbalances in the microbiome (the communities of microbes that live in and on our bodies) to developing new methods for gene editing and programmable control of gene expression.

Carter grew up in northeast South Dakota, where exploring the great outdoors made him curious about biology and life in general. His parents—a farmer and a journalist—nurtured this inquisitiveness and encouraged him to read books on science, math, and engineering. After heading off to Montana for college, Carter chose dual majors in mechanical engineering and microbiology.

Now a senior, Carter is a recipient of one of the university’s competitive undergraduate research internships, which has given him a head start on a career in science.

The views, opinions and positions expressed by these authors and blogs are theirs and do not necessarily represent that of the Bioethics Research Library and Kennedy Institute of Ethics or Georgetown University.