Bioethics Blogs

Making the Connections: Study Links Brain’s Wiring to Human Traits

Caption: The wiring diagram of a human brain, measured in a healthy individual, where the movement of water molecules is measured by diffuse tensor magnetic resonance imaging, revealing the connections. This is an example of the type of work being done by the Human Connectome Project.
Source: Courtesy of the Laboratory of Neuro Imaging and Martinos Center for Biomedical Imaging, Consortium of the Human Connectome Project

For questions about why people often think, act, and perceive the world so differently, the brain is clearly an obvious place to look for answers. However, because the human brain is packed with tens of billions of neurons, which together make trillions of connections, knowing exactly where and how to look remains profoundly challenging.

Undaunted by these complexities, researchers involved in the NIH-funded Human Connectome Project (HCP) have been making progress, as shown by some intriguing recent discoveries. In a study published in Nature Neuroscience [1], an HCP team found that the brains of individuals with “positive” traits—such as strong cognitive skills and a healthy sense of well-being—show stronger connectivity in certain areas of the brain than do those with more “negative” traits—such as tendencies toward anger, rule-breaking, and substance use. While these findings are preliminary, they suggest it may be possible one day to understand, and perhaps even modify, the connections within the brain that are associated with human behavior in all its diversity.

In the new study, Stephen Smith of the Oxford University Centre for Functional MRI of the Brain, United Kingdom and his colleagues measured for an hour the patterns of neural activity and connectivity among 200 distinct brain regions in 461 HCP participants lying still in an MRI scanner.

The views, opinions and positions expressed by these authors and blogs are theirs and do not necessarily represent that of the Bioethics Research Library and Kennedy Institute of Ethics or Georgetown University.