The British Parliament has, recently, passed Act 1990 making possible what is, misleadingly, called “three parents babies,” which will become law in October 2015. Thus, the UK is the first country to allow the transfer of genetic material from an embryo or an egg that has defects in the mitochondrial DNA to generate a healthy baby. As it is perhaps known, a defect in the mitochondrial DNA causes several genetic disorders such as heart and liver failure, blindness, hearing loss, etc. Babies free from these genetic problems are expected to be born next year. This is good news and shows how science and technology can really work for human benefit.
This procedure raised several concerns, but also revealed confusion and misunderstandings in public debates. There was the fear of opening the way to Nazi practices considered intrinsically immoral. This is certainly not the case since the prevention of mitochondrial defects does not, strictly speaking, involves any gene editing, which is a different kind of genetic engineering. Now, embryo editing, which will be illustrated soon, does divide scientists and ethicists and needs further public debate. I will here present some real ethical concerns relating to embryo editing and to comment on the recent call, published by Nature, for a moratorium on the germline experiments.
To start with, let me ask: is mitochondrial DNA transfer a kind of eugenic procedure? Well, in the literal sense “Yes” (good genes), but it represents only what some bioethicists call “negative” or “curative eugenics” not positive enhancement. Now, leaving slippery-slope concerns aside for a moment, there is consensus among ethicists that negative eugenics is permissible and even morally required by the prima facie bioethical principle of non-maleficence, namely harm must be prevented.
The views, opinions and positions expressed by these authors and blogs are theirs and do not necessarily represent that of the Bioethics Research Library and Kennedy Institute of Ethics or Georgetown University.